2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15560
    Hoechst 34580 23555-00-2 99.84%
    Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution.
    Hoechst 34580
  • HY-16171
    Diphenmanil methylsulfate 62-97-5 99.83%
    Diphemanil methylsulfate is a quaternary ammonium anticholinergic.
    Diphenmanil methylsulfate
  • HY-B1132
    Clidinium bromide 3485-62-9 99.42%
    Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.
    Clidinium bromide
  • HY-B1319
    Pramocaine hydrochloride 637-58-1 99.85%
    Pramocaine hydrochloride decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses.
    Pramocaine hydrochloride
  • HY-B2121
    6-Methoxy-2-naphthoic acid 2471-70-7 ≥98.0%
    6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.
    6-Methoxy-2-naphthoic acid
  • HY-D2481
    Asante potassium green-2 TMA 1369302-21-5
    Asante potassium green-2 TMA (APG-2 (TMA)) is a cell-impermeable K+ fluorescent indicator that produces a fluorescent response to changes in extracellular potassium ion concentration (Ex/Em = 525/545 nm).
    Asante potassium green-2 TMA
  • HY-G0003
    Iloperidone metabolite Hydroxy Iloperidone 133454-55-4 99.70%
    Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia.
    Iloperidone metabolite Hydroxy Iloperidone
  • HY-N5086
    Picroside IV 211567-04-3 99.08%
    Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820). Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects.
    Picroside IV
  • HY-N6748
    Roquefortine C 58735-64-1 ≥98.0%
    Roquefortine C is a mycotoxin that can be isolated from Penicillium species. Roquefortine C is an agonist of P-gp and an inhibitor of P450 3A and P450 1A. Roquefortine C can inhibit Gram-positive bacteria and also has certain neurotoxicity. Additionally, Roquefortine C can exert antitumor activity.
    Roquefortine C
  • HY-Y0729
    4-Chlorocinnamic acid 1615-02-7 99.98%
    4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A). 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol.
    4-Chlorocinnamic acid
  • HY-100814
    (R)-CPP 126453-07-4 98.99%
    (R)-CPP is a highly potent NMDA receptor antagonist.
    (R)-CPP
  • HY-101169
    Tetrindole mesylate 170964-68-8 99.93%
    Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity.
    Tetrindole mesylate
  • HY-101352
    LY 225910 133040-77-4 98.92%
    LY 225910 is a selective antagonist for cholecystokinin receptor (CCK2 receptor), which affects the excitatory response to morphine, and leads to morphine sensitization.
    LY 225910
  • HY-103383
    (R)-DRF053 dihydrochloride 1241675-76-2 99.30%
    (R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model.
    (R)-DRF053 dihydrochloride
  • HY-113257
    Dopamine 4-sulfate 38339-02-5
    Dopamine 4-sulfate (DA-4S) is an inactive metabolite of the catecholamine dopamine. It is formed from dopamine by the sulfotransferase (SULT) isoform SULT1A3. Dopamine 4-O-sulfate is found at lower levels in the brain and circulation than dopamine 3-O-sulfate.
    Dopamine 4-sulfate
  • HY-118819
    5-Bromo-3-phenyl salicylic acid 99514-99-5 98.00%
    5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 140 nM.
    5-Bromo-3-phenyl salicylic acid
  • HY-123800
    BI 187004 1303515-32-3 98.13%
    BI 187004 (VTP-34072) is an 11β-hydroxysteroid dehydrogenase 1 inhibitor for use in diabetes research.
    BI 187004
  • HY-124462
    Trifluperidol hydrochloride 2062-77-3 99.4%
    Trifluperidol hydrochloride is a Sigma-1 receptor antagonist with a Ki value of 3.3 nM. Trifluperidol hydrochloride is used in the study of psychosis.
    Trifluperidol hydrochloride
  • HY-12719R
    Dexmedetomidine (Standard) 113775-47-6 99.92%
    Dexmedetomidine (Standard) is the analytical standard of Dexmedetomidine. This product is intended for research and analytical applications. Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects.
    Dexmedetomidine (Standard)
  • HY-134104
    C20-Sphingosine 6918-49-6 99.00%
    C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development.
    C20-Sphingosine
Cat. No. Product Name / Synonyms Application Reactivity